Process for the preparation of enantiomerically pure thienopyran

Details Process for the preparation of enantiomerically pure thienopyran Process for the preparation of enantiomerically pure thienopyran

1994-09-30

1995-10-10

Robinson, Allen J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 60, 548527, 546197, C07D49502, C07D40904, C07D40102, C07D41104

Patent

active

054572126

ABSTRACT:
A process for the preparation of enantiomerically pure thienopyran derivatives of the formula ##STR1## is described. The thienopyran derivatives are relaxants of smooth muscle tone and as such are useful in vascular tissue for the treatment of hypertension disease, angina and other vascular disorders characterized by poor regional perfusion.

REFERENCES:
patent: 4228296 (1980-10-01), Grudzinskas et al.
patent: 4992435 (1991-02-01), Press et al.
patent: 5013853 (1991-05-01), Gericke et al.
patent: 5077307 (1991-12-01), Binder et al.
Pirkle, et al., J. Org. Chem., vol. 44(26), "Dynamic NMR studies of diastereomeric carbamates", pp. 4891-4896 (1979).
Westley et al., J. Org. Chem, vol. 33, "The use of (-)-menthyl chloroformate in the optical analysis . . . ," pp. 3978-3980 (1968).
Gerlach, Helvetica Chimica Acta, vol. 61(8), "Racematspaltung and Bestimmung der absoluten . . . " pp. 2773-2776 (1978).
Ashwood, et al., J. Med. Chem., 1986, vol. 29, No. 11, pp. 2194-2201.
Quagliato, et al., Bio. & Med. Chem. Letts., vol. 1, No. 1, pp. 39-42, 1991.

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