Process for the preparation of enantiomerically pure substituted

Details Process for the preparation of enantiomerically pure substituted Process for the preparation of enantiomerically pure substituted

1992-04-10

1994-04-26

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546154, 546155, 546156, 546168, 546170, 546173, 546174, 546176, 546177, 546178, C07D21500, C07D21512, C07D21516

Patent

active

053068203

ABSTRACT:
(Quinolin-2-yl-methoxy)phenylacetic acids are known as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.
Enantiomerically pure (quinolin-2-yl-methoxy)phenylacetic acids can be prepared in a simple manner and in high purity and yield by diastereoselective alkylation of corresponding (quinolin-2-yl-methoxy)phenylacetic acid menthyl esters and subsequent specific removal of the ester radical with acids.

REFERENCES:
patent: 4970215 (1990-11-01), Mohrs et al.
patent: 5091392 (1992-02-01), Raddatz et al.
CA 113(9) 78180e, (1990).
CA 113(7) 58959n, (1989).
Chemical Abstracts Service 117:19908 (1992).
Fuji et al., "Binaphthol as a Chiral Auxiliary . . . ", Tetrahedron Letters, vol. 30, No. 21, (1989), pp. 2825-2828.
A. Guy et al., "Stereoselective Acetoxylation of Chiral . . . ", Tetrahedron Letters, vol. 30, No. 3, (1989), pp. 327-330.
A. Ando et al., "Asymmetric Synthesis using Chiral Bases . . . ", J. Chem. Soc., Chem. Commun. (1987), pp. 656-661.
M. Lemaire et al., "Asymmetric Control of Oxidation of Aromatic . . . ", J. Chem. Soc., Chem. Commun. (1986), pp. 741-742.
G. E. Jeromin et al., "Seitenkettenchlorierungen von N-heterocyclen . . . ", Chem. Ber. vol. 120 (1987), pp. 649-651.
Beilstein: Syst. No. 452, pp. 15, 29 and 43.

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