Process for the preparation of enantiomerically pure cycloalkano

Details Process for the preparation of enantiomerically pure cycloalkano Process for the preparation of enantiomerically pure cycloalkano

1997-03-31

1999-09-14

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544249, 546 84, 546 85, 546 86, 546 87, 548400, 548416, 548427, 514267, 514292, C07D47104, C07D48704, C07C 69616, C07C 69612

Patent

active

059524987

ABSTRACT:
The invention relates to a process and intermediates for the preparation of enantiomerically pure cycloalkanoindolecarboxylic acids and their activated derivatives, characterized in that the tolyl acetic acid is first esterified with a chiral alcohol, then diastereoselective substitution at .alpha.-carbon atoms is carried out and this product is halogenated in the tolyl group and then reacted with appropriate possible by this method to prepare specifically, in high purity, the enantiomerically pure carboxylic acids which are intermediates for valuable medicaments.

REFERENCES:
patent: 4970215 (1990-11-01), Mohrs et al.
patent: 5527809 (1996-06-01), Muller-Gliemann et al.
patent: 5684014 (1997-11-01), Muller et al.

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