Process for the preparation of eletriptan

Details Process for the preparation of eletriptan Process for the preparation of eletriptan

2007-10-30

2007-10-30

Richter, Johann (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10974670

ABSTRACT:
The present invention provides an improved process for the preparation of the anti-migraine drug, (R)-5-(2-benzenesulphonylethyl)-3-N-methylpyrrolidin-2-ylmethyl)-1H-indole (eletriptan), available commercially as the hydrobromide salt, and an intermediate and dimer-free products obtained from such process.

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Kojima, wt al., “Fluorescent Properties of Model Chromophores of Tyrosine-66 Substituted Mutants of Aequorea Green Fluorescent Protein”, Tetrahedron Letters, 1998, pp. 5239-5242, vol. 39, No. 29.
Willems, et al., “Porcine Carotid Vascular Effects of Eletriptan (UK-0116,044): A New 5-HT1b/1D Receptor Agonist with Anti-Migraine Activity”, Naunyn-Scmiedeberg's Arch Pharmacology, 1998, pp. 212-219, vol. 358, No. 2.

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