Process for the preparation of E-2-propyl-2-pentenoic acid and p

Details Process for the preparation of E-2-propyl-2-pentenoic acid and p Process for the preparation of E-2-propyl-2-pentenoic acid and p

1988-06-02

1990-10-30

Garner, Vivian

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560213, C07C 2702, C07C 5141, C07C 5703

Patent

active

049669966

ABSTRACT:
A novel process for the preparation of E-2-propyl-2-pentenoic acid, as well as the physiologically compatible salts thereof is described, in which 2-bromo-2-propyl-pentenoic acid ethyl ester is used as the starting compound. The bromine is split off with a cyclic tertiary amine in acetonitrile as the solvent and preferably the E-isomer of the ethyl ester is formed. The free acid is obtained by subsequent saponification under careful conditions and optionally, preferably using the corresponding carbon dioxide salts in aqueous acetone solution, is converted into the salt form.

REFERENCES:
patent: 2376067 (1945-05-01), Long
patent: 2679530 (1954-05-01), Porret
patent: 4337209 (1982-06-01), Akers et al.
Wagner et al., Synthetic Organic Chemistry, John Wiley & Sons, Inc., N.Y. 1953, p. 417.

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