Process for the preparation of dispersible colloidal systems of

Coating processes – Particles – flakes – or granules coated or encapsulated – Solid encapsulation process utilizing an emulsion or...

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264 41, 264 46, 424469, 424485, 424486, 424487, 4284022, 42840221, 514965, A61K 951, B01J 1306, B01J

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051185288

ABSTRACT:
The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance, (3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance, and (4) is desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to produce a powder of nanoparticles.

REFERENCES:
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 4492720 (1985-01-01), Mosier
patent: 4585651 (1986-04-01), Beck et al.

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