Process for the preparation of dimeric alkaloids

Details Process for the preparation of dimeric alkaloids Process for the preparation of dimeric alkaloids

1985-01-04

1987-04-21

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546 51, C07D51904

Patent

active

046598162

ABSTRACT:
A process is disclosed for the preparation of dimeric alkaloids of formula (II) ##STR1## wherein R stands for methyl or formyl, as well as acid addition salts thereof which comprises oxidizing the vinblastine of formula (III) ##STR2## with chromium (VI) oxide or bichromate or chromic acid alcohol ester in an inert solvent, converting the compound of formula (II), wherein R stands for methyl, so obtained to the acid addition salt and optionally further oxidizing the acid addition salt obtained with an oxidizing agent as defined above and optionally converting the compound of formula (II), wherein R stands for formyl, so obtained to the acid addition salt.

REFERENCES:
patent: 3481937 (1969-12-01), Renner et al.
patent: 3899493 (1975-08-01), Jovanovics et al.
patent: 4303584 (1981-12-01), Pearce
patent: 4375432 (1983-03-01), Conrad
Ziegler, et al., J. Am. Chem. Soc., vol. 95, No. 22, pp. 7458-7464 (1973).
Langlois, et al., Helv. Chim. Acta, vol. 63, No. 4, pp. 793-805 (1980).
Doe de Maindreville, et al., Bull. Soc. Chim. France, 1981, (5-6, Pt. 2), pp. 179-184 (1981).

Affiliated with

Also associated with

Rating

Process for the preparation of dimeric alkaloids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of dimeric alkaloids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of dimeric alkaloids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-753102