Process for the preparation of diisopinocampheylchloroborane

Details Process for the preparation of diisopinocampheylchloroborane Process for the preparation of diisopinocampheylchloroborane

1994-08-11

1996-08-13

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Boron containing

C07F 502

Patent

active

055457584

ABSTRACT:
The present invention relates to an improved process for the in situ preparation of diisopinocampheylchloroborane which comprises reacting sodium borohydride and boron trichloride with .alpha.-pinene. The diisopinocampheylchloroborane thus obtained may be used, without isolation, to reduce prochiral ketones to their corresponding alcohols in high optical purity.

REFERENCES:
patent: 5043479 (1991-08-01), Brown
patent: 5220077 (1993-06-01), Brown
patent: 5292946 (1994-03-01), Simpson et al.
J. Am. Chem. Soc., 1983, 105, 2092-2093, Brown et al.
Brown, H. C. and Ravindran N., J. Am. Chem. Soc., 1972, 94, 2112-3.
J. Org. Chem., 1987, 52, 5406, Brown et al.
Brown, H. C., et al, J. Org. Chem., 1986, 51, 3394.
J. Org. Chem., 1988, 53, 2916, Brown et al.
J. Am. Chem. Soc., 1988, 1539, Brown et al.
J. Org. Chem., 1993, 58, 3731-5, King et al.

Affiliated with

Also associated with

Rating

Process for the preparation of diisopinocampheylchloroborane does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of diisopinocampheylchloroborane, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of diisopinocampheylchloroborane will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1048920