Organic compounds -- part of the class 532-570 series – Organic compounds – Boron containing
Patent
1994-08-11
1996-08-13
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Boron containing
C07F 502
Patent
active
055457584
ABSTRACT:
The present invention relates to an improved process for the in situ preparation of diisopinocampheylchloroborane which comprises reacting sodium borohydride and boron trichloride with .alpha.-pinene. The diisopinocampheylchloroborane thus obtained may be used, without isolation, to reduce prochiral ketones to their corresponding alcohols in high optical purity.
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King Anthony O.
Larsen Robert D.
Verhoeven Thomas R.
Zhao Mangzhu
Merck & Co. , Inc.
Reamer James H.
Rose David L.
Yang Mollie M.
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