Process for the preparation of diisopinocampheylchloroborane

Details Process for the preparation of diisopinocampheylchloroborane Process for the preparation of diisopinocampheylchloroborane

1996-01-16

1997-12-02

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21514

Patent

active

056938160

ABSTRACT:
The present invention relates to an improved process for the in situ preparation of diisopinocampheylchloroborane which comprises reacting sodium borohydride and boron trichloride with .alpha.-pinene. The diisopinocampheylchloroborane thus obtained may be used, without isolation, to reduce prochiral ketones to their corresponding alcohols in high optical purity.

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J. Am. Chem. Soc., 1983, 105, 2092-2093, Brown, et al.
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J. Am. Chem., Soc., 1988, 1539-1546, vol. 110, Brown, et al.
J. Org. Chem., 1993, 58, 3731-3735, King, et al.

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