Process for the preparation of dihydroartemisinin hemisuccinate

Details Process for the preparation of dihydroartemisinin hemisuccinate Process for the preparation of dihydroartemisinin hemisuccinate

1996-03-27

1997-08-05

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D32100

Patent

active

056544464

ABSTRACT:
Dihydroartemisinin hemisuccinate is prepared by acylation of dihydroartemisinin with 1.0 to 1.3 molar equivalents of succinic anhydride in the presence of 0.5 to 1.5 molar equivalents of tri(C.sub.1 -C.sub.3 -alkyl)amine in a low-boiling, neutral, water-miscible, inert organic solvent or solvent mixture and subsequent isolation of the product at pH 5-8. The product is obtained directly in crystalline form and high yield.

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