Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H

Details Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H

1986-03-21

1987-05-05

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548551, C07D48706, C07D48708

Patent

active

046634649

ABSTRACT:
Dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione is produced in higher overall yield in a process which comprises catalytically hydrogenating a lower alkyl ester of 4-(hydroxyimino)heptanedioic acid in the presence of a tri-(lower alkyl)amine, followed by cyclization of the product thus produced in the presence of a cyclizing agent such as acetic anhydride.

REFERENCES:
patent: 4372966 (1983-02-01), Butler
patent: 4548947 (1985-10-01), Butler et al.
patent: 4563469 (1986-01-01), Butler et al.
patent: 4581462 (1986-04-01), Yankee et al.
Leonard, et al.; J. Am. Chem. Soc., 69, (1947), pp. 690-692.
Micheel, et al.; Chem. Ber., 88, (1955), pp. 509-510.
Micheel, et al.; Ann. Chem., 581, (1953), pp. 225-237.
Lukes et al., Coll. Czech. Cham. Comm., 12:278-279 (1947).

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