Process for the preparation of dihaloazolopyrimidines

Details Process for the preparation of dihaloazolopyrimidines Process for the preparation of dihaloazolopyrimidines

1996-10-15

1998-09-15

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

C07D48704

Patent

active

058080660

ABSTRACT:
An effective and efficient process for the preparation of a dihaloazolopyrimidine having the structural formula ##STR1## In this process, a malonic acid ester is reacted with a heterocyclylamine to form an intermediate salt, which optionally may be acidified to form a dihydroxyazolopyrimidine; the salt or the dihydroxyazolopyrimidine is then halogenated.

REFERENCES:
patent: 3907799 (1975-09-01), O'Brien et al.
patent: 5006656 (1991-04-01), Shankar et al.
G. Fisher, Advances in Heterocyclic Chemistry, 1993, 57, 81-138.
Y. Makisumi, Chem. Pharm. Bull., 1961, 9, 801-808.

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