Process for the preparation of dibenzothiepin derivative

Details Process for the preparation of dibenzothiepin derivative Process for the preparation of dibenzothiepin derivative

1987-09-30

1990-01-02

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 9, 560152, 560153, 562431, C07D33714, C07C14940

Patent

active

048914339

ABSTRACT:
A novel process for the preparation of 2-(10,11-dihydro-10-oxodibenzo[b, f]thiepin-2-yl)propionic acid which shows high anti-inflammatory and analgetic action is disclosed. The process starts from a propiophenone derivative having the formula (II): ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group, which is once converted into a haloacetal compound via a halo-ketone compound, and then converted into the desired dibenzothiepin derivative through a combination of rearrangement, hydrolysis and ring closure in variable sequences.

REFERENCES:
patent: 4247706 (1981-01-01), Fujimoto et al.
Patent Abstracts of Japan, vol. 7, No. 213, p. 132.
Patent Abstracts of Japan, vol. 6, No. 197, p. 54.
Streitwieser & Heathcock, Introduction to Organic Chemistry, pp. 766-767.

Affiliated with

Also associated with

Rating

Process for the preparation of dibenzothiepin derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of dibenzothiepin derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of dibenzothiepin derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1384319