Process for the preparation of diacylimides

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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540362, 540451, 540529, 546221, 546245, 548530, 548539, 548540, 564152, 564155, 564159, C07D20508, C07D22310, C07D21122, C07D29500, C07C23300

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060281928

ABSTRACT:
The present invention relates to a process for the preparation of compounds of the formula 1 ##STR1## by reacting a secondary acid amide of the formula 2 ##STR2## with an acid chloride of the formula 3 ##STR3## in the presence of N,N-diisopropyl-N-ethylamine. R.sup.1, R.sup.2 and R.sup.3 are alkyl or alkenyl radicals, if required also aryl radicals. The compounds of the formula 1 are suitable for use as insecticides or bleach activators.

REFERENCES:
Elsevier Science Ltd., PII: S0040-4039(96)02417-3, Mekonnen and Ziffer, A New Route to N-Substituted 11-Azaartemisinins, 1997.
XP-002082623, H. Sasaki et al.: "Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives" Journal of Medicinal Chemistry, Bd. 34, Nr. 2, 1991, pp. 628-633.
XP-002082624, M. Bodanszky et al.: "Side reactions in peptide synthesis. II. Formation of succinimide derivatives from aspartyl residues" Journal of Organic Chemistry, Bd. 40, Nr. 17, 1975, pp. 2495-2499.
XP002082625, T. Tsunoda et al.: "An efficient method for hydrolysis of N-monosubstituted amides via acetoxypivalimides" Tetrahedron Letters, Bd. 31, Nr. 5, 1990, pp. 731-734.
XP-002082626, F.M.F. Chen et al.: "Diisopropylamine eliminates dipeptide formation during the acylation of amino acids using benzoyl chloride and some alkyl chloroformates" Canadian Journal of Chemistry, Bd. 65, 1987, pp. 1224-1227.

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