Process for the preparation of di- and trialkyl-4'-phthalimidome

Details Process for the preparation of di- and trialkyl-4'-phthalimidome Process for the preparation of di- and trialkyl-4'-phthalimidome

1990-10-31

1992-03-24

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548452, C07D40512

Patent

active

050990314

ABSTRACT:
Di- and trialkyl-4'-phthalimidomethyl-furocoumarins are prepared by reacting di- or trialkyl-furocoumarins in the presence of an acid and, if appropriate, of a polar solvent with a compound of the formula (I) ##STR1## in which R" represents hydrogen, a second phthalimidomethyl group, C.sub.1 - to C.sub.4 -alkyl or C.sub.1 - to C.sub.6 -acyl,
where, when using trialkyl-furocoumarins, R" does not represent hydrogen.

REFERENCES:
patent: 3979393 (1976-09-01), Kvita et al.
Isaacs et al., J. Labelled Compounds and Radio Pharmaceuticals vol. XIX, No. 3, pp. 345-356 (1981).
A. Guitto et al., Eur. J. Med. Chem., 16, pp. 489-494 Synthesis of some photosensitizing methylangelicins, as monofunctional reagents for DNA (1981).
F. Dall'Acqua et al., J. Med. Chem., 24(2), pp. 178-184 New Monofunctional Reagents for DNA as Possible Agents for the Photochemotherapy of Psoriasis: Derivatives of 4,5'-Dimethyllangelicin (1981).

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