Process for the preparation of detoxified polysaccharide-outer m

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

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530403, 530350, 530412, 530418, 530419, 530420, 530422, 530825, 424 88, 424 92, 435849, 435851, 435871, 435875, C07K 324, C07K 1504

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047075430

ABSTRACT:
Process for preparing a detoxified polysaccharide-outer membrane protein complex from bacterial envelopes; the so-obtained products which are useful as vaccines against infection by the same bacteria and method for protecting animals against the same infection by administration of a pharmaceutical composition containing the detoxified polysaccharide-outer membrane protein complexes.

REFERENCES:
patent: 4185090 (1980-01-01), McIntire
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4372883 (1983-02-01), Matuhashi et al.
patent: 4451446 (1984-05-01), Vandevelde
patent: 4459286 (1984-07-01), Hilleman et al.
patent: 4474756 (1984-10-01), Mitsuhashi et al.
Seid et al, JBC, 1981, pp. 7305-7310, Preparation and Characterization of toxified Lipapaleparcharide Protein Conjugate.

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