Process for the preparation of derivatives of quinuclidine subst

Details Process for the preparation of derivatives of quinuclidine subst Process for the preparation of derivatives of quinuclidine subst

1983-08-11

1985-10-08

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45302

Patent

active

045461856

ABSTRACT:
Process for the preparation of compounds of the formula: ##STR1## in which X is H, Cl, Br, I or OH, in which 3-methylene quinuclidine is reacted with an aluminum hydride, in an appropriate solvent and in the presence of a catalytic quantity of a halide of a transition metal, the molar ratio ##EQU1## being at least equal to 0.6, the product formed is reacted in situ with an ester, and then the product thus formed is reacted in situ with an electrophilic reactant which is capable of yielding an atom or group X as defined with reference to formula (I). The compounds of formula (I) can be used for the preparation of medicaments.

REFERENCES:
Chemical Abstracts, 90:5881f (1979) [Sato, M., et al., Jpn. Kokai 78, 103, 426, 9/8/78].
Chemical Abstracts, 97:92548p (1982) [Sato, M., Jpn. Kokai 82, 26, 694, 2/12/82].
Ashby E., et al., J. Org. Chem., 45,1035 (1980).

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