Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-09-04
1993-05-18
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536120, C07H 100
Patent
active
052122930
ABSTRACT:
An improved process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a substituted organoaluminum compound which exhibits greater solubility in conventional solvents than AlF.sub.3.
REFERENCES:
patent: 3775397 (1973-11-01), Etzold et al.
Etzold, G. et al., Tetrahedron, (1971) 27: 2463-2742.
Kowallik, V. G. et al., J. F. Prakt. Chemie., (1973) 315: 895-900.
Herdewijn, P. et al., J. Med. Chem., (1987) 30: 1270-1278.
Van Aerschot, A. et al., J. Med. Chem., (1979) 32: 1743-1749.
Considine, Jr. John L.
D'Antuono, III Joseph
Green Kenneth E.
Padmanathan Thurairajah
American Cyanamid Company
Brown Johnnie R.
Dow Kenneth J.
Wilson J. Oliver
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