Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2011-03-08
2011-03-08
Saeed, Kamal A (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S105000
Reexamination Certificate
active
07902357
ABSTRACT:
A process for the preparation of delmopinol (3-(4-propylheptyl)-4-morpholinethanol) or a derivative or a pharmaceutically acceptable salt, or a solvate thereof, including an hydrate, comprises reacting oxazolidin [2, 3-c] morpholine and a grignard reagent, and optionally converting the delmopinol (or derivative) free base into a pharmaceutically acceptable salt. The oxazolidin [2, 3-c] morpholine and the grignard reagent are useful as intermediates in the production process.
REFERENCES:
patent: 4595751 (1986-06-01), Blanc
patent: 0 038 785 (1981-10-01), None
patent: WO 90/14342 (1990-11-01), None
Vippagunta, et al. Crystalline Solids, Advanced Drug Delivery Reviews 48 (2001) 3-26.
Mealy N., et al. “Delmopinol hydrochloride. Dental plaque formation inhibitor, treatment of gingivitis”Drugs of the Future, Aug. 1996, pp. 787-791, vol. 21, No. 8.
Poerwono H., et al. “Stereocontrolled Preparation of cis- and trans-2,6-Dialkylpiperidines via Diastereoselective Reaction of 1-Aza-4-oxabicyclo[4.3.0] nonane Derivatives with Grignard Reagents”Tetrahedron, Nov. 12, 1998, pp. 13955-13970, vol. 54, No. 46.
Artus Surroca Juan Jose
Fernandez Bleda David
Iacoangeli Tommaso
Lluis Tous Jordi
Grazier Nyeemah
Saeed Kamal A
Saliwanchik Lloyd & Eisenschenk
Sinclair Pharmaceuticals Limited
LandOfFree
Process for the preparation of delmopinol and derivatives... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of delmopinol and derivatives..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of delmopinol and derivatives... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2742670