Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1980-03-07
1982-12-07
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435253, 435 55, C12N 1500, C12N 120, C12P 3316
Patent
active
043628150
ABSTRACT:
For the production of 17-C-steroid-.alpha.-propionic acid compounds by microbial side chain degradation on 17-C-side chain steroid substrates wild strain microorganisms selected in predetermined manner are subjected to a multi-stage mutation and selection. The resultant mutant strains are capable of supplying the desired compounds, e.g. .DELTA.-4 BNC and/or .DELTA.-1,4 BNC in high yields even in the absence of inhibitors arresting the growth and/or degradation of the steroid ring. Wild strains and mutants particularly suitable, and their choice, production and use, are described.
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Lamanna et al., Basic Bacteriology, Its Biological and Chemical Background, 3rd Ed., The Williams & Wilkins Co., pp. 723-727, (1965).
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Martin et al., European J. Appl. Microbial, vol. 2, pp. 243-255, (1976).
Hill Frank F.
Preuss Wolfgang
Schindler Joachim
Schmid Rolf
Struve Alfred
Collins Forrest L.
Henkel Kommanditgesellschaft auf Aktien
Tanenholtz Alvin E.
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