Process for the preparation of D(+)-biotin

Details Process for the preparation of D(+)-biotin Process for the preparation of D(+)-biotin

1982-06-07

1984-05-22

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549435, 549454, C07D49504

Patent

active

044502761

ABSTRACT:
The stereospecific preparation of D(+)-biotin is improved by a synthetic route involving the conversion of 3,4-isopropylidene-D-arabinose in which the OH group in the 2-position is not protected, into an ester of 6,9-dihydroxy-7,8-isopropylidenedioxynona-2,4-dienoic acid, the latter then being catalytically hydrogenated and subsequently converted into D(+)-biotin in a manner known per se.

REFERENCES:
Vogel, F., et al., Liebigs Ann. Chem., 1980, 1972-1977.

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