Process for the preparation of D(-) and L(+)-3,3-diphenylalanine

Details Process for the preparation of D(-) and L(+)-3,3-diphenylalanine Process for the preparation of D(-) and L(+)-3,3-diphenylalanine

1992-01-30

1993-03-30

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546134, 560 27, 560 38, 560 40, 562401, 562441, C07D45302, C07B 5700, C07C27132, C07C27154

Patent

active

051985489

ABSTRACT:
A process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines is described where N-protected DL-3,3-diphenylalanine or N-protected-DL-substituted 3,3-diphenylalanine are treated with (-)cinchonidine and the resulting salt resolved into the desired enantiomers, as well as derivatives thereof and valuable intermediates used in the process.

REFERENCES:
patent: 4603145 (1986-07-01), DeVries et al.
patent: 4988730 (1991-01-01), Korbonits et al.
Tetrahedron Letters, vol. 32, No. 45, pp. 6547-6550, (1991).

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