Process for the preparation of D-.alpha.-amino acids

Details Process for the preparation of D-.alpha.-amino acids Process for the preparation of D-.alpha.-amino acids

1996-11-06

1998-11-10

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

43525231, 43525233, 4353201, 935 22, C12P 1304, C12N 120, C12N 1500

Patent

active

058342583

ABSTRACT:
In an improved process for the preparation of D-.alpha.-amino acids by the stereoselective conversion of racemic mixtures of 5-substituted hydantoins with an enzymatic system produced by a microorganism, the improvement consists in the fact that a microorganism is used which is transformed with the plasmid pSM700 cultivated at a temperature of between 20.degree. C. and 28.degree. C. The use of this microorganism allows an improvement in the expression of the enzymatic system and an increase in the conversion rate of the racemic hydantoin to D-.alpha.-amino acid.

REFERENCES:
Kim et al. (1995) Optimization of the enzymatic synthesis of D-p-hydroxyphenylglycine from DL-5-substituted hydantoin using D-hydantoinase and N-carbomoylase, Enzyme and Microbial Technology 17: 63-67, Jan. 1995.
Deepa et al. (1993) Enzymatic production and isolation of D-amino acids from the corresponding 5-substituted hydantoins. Process Biochemistry 28: 447-452, Apr. 1993.

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