Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1991-03-14
1993-05-11
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
560 39, 562444, C07B 5700, C07C22942
Patent
active
052102882
ABSTRACT:
The invention relates to a process for the preparation of D-(-)-4-hydroxyphenylglycine and L-(+)-4-hydroxyphenylglycine starting from D.L.-4-hydroxyphenylglycine. According to the invention the D.L.-4-hydroxyphenylglycine is dissolved in a suitable solvent or a mixture of solvents at an increased temperature, which solvent mixture comprises an organic solvent, H.sub.2 SO.sub.4 and water. Then the solution obtained is cooled and to the cooled solution are added D-(-)-4-hydroxyphenylglycine sulphate inoculation crystals for crystallizing the D-(-)-4-hydroxyphenylglycine sulphate, followed by filtering of the formed crystals. For recovery of L-(+)-4-hydroxyphenylglycine sulphate remaining in the mother liquor, the mother liquor is heated, followed by addition of D.L.-4-hydroxyphenylglycine and a solution of H.sub.2 SO.sub.4 and water. The resulting solution is cooled down, followed by addition of L-(+)-4-hydroxyphenylglycine sulphate inoculation crystals, from which mixture after further cooling the L-(+)-4-hydroxyphenylglycine sulphate crystallizes.
REFERENCES:
patent: 3994962 (1976-11-01), Shirai et al.
Frazier B.
Killos Paul J.
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