Process for the preparation of cytosines

Details Process for the preparation of cytosines Process for the preparation of cytosines

1990-01-03

1991-06-25

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23947

Patent

active

050268520

ABSTRACT:
Cytosines which may optionally be substituted in the 5 position are prepared by a simplified process in which urea is reacted with an alcoholate and an alkoxy-acrylonitrile or dialkoxy-propionitrile in a sparsely water-miscible organic solvent which is inert under the reaction conditions. The use of such a solvent makes it possible to react the mentioned reactants in simple fashion without isolation of an intermediate stage, and to reuse the organic solvent without a separate purification.

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