Process for the preparation of cyclosporin derivatives

Details Process for the preparation of cyclosporin derivatives Process for the preparation of cyclosporin derivatives

2007-06-05

2007-06-05

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S009100, C530S317000, C530S321000, C530S335000, C530S336000, C530S337000

Reexamination Certificate

active

09742008

ABSTRACT:
The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or several free hydroxy groups and/or non-methylated nitrogen atoms in position α and/or any other acid group capable of deprotonation which are optionally deprotonated or in protected form.

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