Process for the preparation of cyclosporin a from tolypocladium

Details Process for the preparation of cyclosporin a from tolypocladium Process for the preparation of cyclosporin a from tolypocladium

1995-06-16

1997-08-12

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 711, 4352541, 435911, C12P 2104, C12P 2100, C12N 114

Patent

active

056564597

ABSTRACT:
The invention relates to a process for the preparation of cyclosporin A from Tolypocladium Sp comprising in the step of preparing a fermented medium of said Tolypocladium sp. The fungal biomass is extracted of said fermented medium to obtain a methanol extract, which methanol is removed by evaporation to obtain a first residue. An ethyl acetate extract is prepared from the aqueous solution of said first residue, which is decolourized and concentrated to obtain a second residue, the second residue is subjected to a step of purification.

REFERENCES:
patent: 4289851 (1981-09-01), Traber et al.
patent: 5256547 (1993-10-01), Andat et al.
patent: 5382655 (1995-01-01), Seanya et al.
patent: 5447854 (1995-09-01), Goto et al.

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