Process for the preparation of cyclopenta[g]quinazoline...

Details Process for the preparation of cyclopenta[g]quinazoline... Process for the preparation of cyclopenta[g]quinazoline...

2007-07-31

2007-07-31

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S001000, C544S224000

Reexamination Certificate

active

10487863

ABSTRACT:
Cyclopenta[g]quinazolines of formula (I), and esters and amides thereof may be made by reacting an ester or amide of formula (II); or a protected derivative thereof with a complex containing the (propargyl)Co2(CO)6+ion

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Bavetsias, V. et al; “Design and Synthesis of Cyclopenta′g!quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents”;Journal of Medicinal Chemistry, American Chemical Society, Wash., US, vol. 43, No. 10, 2000, pp. 1910-1926-26; XP002187697.
Melin, C. et al; “Novel cyclopenta′g!quinazoline dipeptide antifolates: Thymidylate synthase inhibitors with activity independent of the reduced folate carrier and folylpolyglutamate synthetase”,Chemistry and Biology of Peteridines and Folates; 1997, Proceedings of the Int'l Symposium on Pteridines and Folates, 11th, Berchtesgaden, Germany; Eds. Pfleiderer, Wolfgang; Rokos, Hartmut; Publ.: Blackwell Wissenschafts-VErlag; Jun. 15-20, 1997, pp. 139-144, XP009000407.
Bavetsias, V. , et al; “Synthetis and antitumour activity of cyclopenta′g!quinazoline-based antifolates, a novel class of thymidylate synthase (TS) inhibitors”;Chemistry and Biology of Pteridines and Folates 1997, Proceedings of the Int'l Symposium on Pteridines and Folates, 11th, Berchtesgaden, Germany, Eds.: Pfleiderer, Wolfgang; Rokos, Hartmut; Publ.: Blackwell Wissenschafts-Verlag, Jun. 15-20, 1997, pp. 205-208, XP009000408.
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