Process for the preparation of cycloalkylidenemethylphenylacetic

Details Process for the preparation of cycloalkylidenemethylphenylacetic Process for the preparation of cycloalkylidenemethylphenylacetic

1980-10-14

1982-12-21

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562459, C07C 6976

Patent

active

043650767

ABSTRACT:
Novel 4-(2-oxo-1-cycloalkylidenemethyl)phenylacetic acid derivatives and non-toxic pharmaceutically acceptable salts thereof are useful as anti-inflammatory agents.
The compounds may be prepared by reacting a p-formylphenylacetic acid ester derivative with an enamine of cycloalkanone and hydrolyzing the resulting product, or with a cycloalkanone in the presence of a base.

REFERENCES:
Baltzly, R. JACS 77 624-628 (1955).

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