Process for the preparation of cyclic 4-oxoamidines

Details Process for the preparation of cyclic 4-oxoamidines Process for the preparation of cyclic 4-oxoamidines

1999-03-25

2000-03-14

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483261, C07D23502

Patent

active

060374748

ABSTRACT:
The present invention relates to a process for the preparation of cyclic 4-oxoamidines. Such substances are precursors of active substances having biological action. The process according to the invention forms a further method of obtaining this class of compound.
By reacting condensation products of aldehydes and aminonitriles or amino acid amides with oxidizing agents, the desired cyclic 4-oxoamidines are obtained according to the invention in good to very good yields.

REFERENCES:
patent: 2602799 (1952-07-01), Goldberg et al.
patent: 4280008 (1981-07-01), Schoellkopf et al.
patent: 5698704 (1997-12-01), Jackson
patent: 5910595 (1999-06-01), Durrwachter
Wiering et al, Recuiel De Travaux Chemique, vol. III, pp. 284 to 288 (1971) .

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