Process for the preparation of contrast agents

Details Process for the preparation of contrast agents Process for the preparation of contrast agents

1997-04-21

1998-11-24

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562433, 564163, C07C22900, C07C23300

Patent

active

058409670

ABSTRACT:
The invention provides a process for the preparation of an N-alkyl-acylamino-phenyl-carboxylic acid or carboxylic acid derivative by liquid phase acylation and subsequent N-alkylation of a corresponding amino-phenyl-carboxylic acid (or carboxylic acid derivative), the improvement comprising the addition of an alkylating agent to a solution containing the reaction products of said acylation, to effect said N-alkylation.

REFERENCES:
patent: 4250113 (1981-02-01), Nordal et al.
Kjemi No. Jun. 1990 pp. 6-8, Gulbrandsen T.

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