Process for the preparation of complex compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing

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556 1, 556 41, 556 50, 556116, 556138, 556146, C07F 500, C07F 1300, C07F 1500

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active

050515233

ABSTRACT:
There is disclosed a process for the preparation of analytically pure chelate complexes which can be used in diagnostic medicine, for example as contrast media or radiopharmaceuticals. The process comprises transcomplexing a complex of a .beta.-dicarbonyl compound and a metal ion, for example a metal acetylacetonate, which is readily soluble in an organic solvent that is not miscible in all proportions with water, with a stoichiometric amount or with a less than equivalent amount of a chelating agent whose binding affinity for the metal ion is greater than that of the .beta.-dicarbonyl compound.

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patent: 4714607 (1987-12-01), Klaveness
patent: 4758422 (1988-07-01), Quay

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