Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1989-01-13
1991-09-24
Prescott, Arthur C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
556 1, 556 41, 556 50, 556116, 556138, 556146, C07F 500, C07F 1300, C07F 1500
Patent
active
050515233
ABSTRACT:
There is disclosed a process for the preparation of analytically pure chelate complexes which can be used in diagnostic medicine, for example as contrast media or radiopharmaceuticals. The process comprises transcomplexing a complex of a .beta.-dicarbonyl compound and a metal ion, for example a metal acetylacetonate, which is readily soluble in an organic solvent that is not miscible in all proportions with water, with a stoichiometric amount or with a less than equivalent amount of a chelating agent whose binding affinity for the metal ion is greater than that of the .beta.-dicarbonyl compound.
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Moerker Theophile
Peter Heinrich H.
Ciba-Geigy Corporation
Fishman Irving M.
Prescott Arthur C.
Villamizer JoAnn
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