Process for the preparation of codeine from morphine

Details Process for the preparation of codeine from morphine Process for the preparation of codeine from morphine

1986-12-10

1988-08-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48902

Patent

active

047646152

ABSTRACT:
Codeine is prepared by reacting morphine with trimethyl phenyl ammonium chloride in the presence of an alkali metal carbonate and a hydrocarbon solvent at a temperature of from 40.degree. to 120.degree. C. Codeine is recovered from the reaction mixture. Codeine is useful as an analgesic and antitussive drug.

REFERENCES:
Shaposhnikov, Chemical Abstracts, vol. 31:8833.sup.6 (1937).
Heumann, Chemical Abstracts, vol. 53:4649h (1959).
Kesselring, et al., Chemical Abstracts, vol. 54:3485e (1960).
Stanev, et al., Chemical Abstracts, vol. 55:7460f (1961).

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