Process for the preparation of cis-hexahydroisoindoline derivati

Details Process for the preparation of cis-hexahydroisoindoline derivati Process for the preparation of cis-hexahydroisoindoline derivati

1998-08-04

1999-08-03

Powers, Fiona T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20944

Patent

active

059327448

ABSTRACT:
The instant invention provides a process for the industrial preparation of cis-hexahydroisoindoline derivatives in high yields and stereoselective manner. The instant invention relates to a process for the preparation of cis-hexahydroisoindoline derivative of formula II ##STR1## wherein R.sup.2 is hydrogen, alkyl, benzyl, acyl or alkoxycarbonyl, by catalytic reduction of isoindoline derivative of formula I ##STR2## wherein R.sup.1 is hydrogen, alkyl, benzyl, acyl or alkoxycarbonyl, wherein the catalytic reduction is carried out in the presence of a ruthenium, a rhodium or a palladium catalyst.

REFERENCES:
patent: 5202335 (1993-04-01), Sato et al.
patent: 5409929 (1995-04-01), Ciganek
Dunet et al., Bull. Chem. Soc. France, 1956, 906-910.

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