Process for the preparation of chlorothiazole derivatives

Details Process for the preparation of chlorothiazole derivatives Process for the preparation of chlorothiazole derivatives

1991-03-07

1993-01-19

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548205, C07D27732

Patent

active

051808331

ABSTRACT:
Novel processes for preparing 2-chlorothiazoles, useful as an intermediate for insecticides, from allyl isothiocyanate derivatives having the formula [II]: ##STR1## wherein X represents a leaving group, are simple and convenient reaction procedures under mild conditions without need of a large excess of a chlorinating agent. Further, processes for preparing 5-(aminomethyl)-2-chlorothiazole or salts thereof from the compound [II] achieve higher yields by simple, convenient and inexpensive procedures.

REFERENCES:
patent: 4742060 (1988-05-01), Shiokawa et al.
patent: 4748243 (1988-05-01), Beck
patent: 4845106 (1989-07-01), Shiokawa et al.
March, Advanced Organic Chemistry pp. 364-366 (1985).
Fieser Reagents for Organic Synthesis p. 428 (1987).
Potts, Comprehensive Heterocyclic Chemistry, vol. 6, pp. 295, 6, 311 (1984).
G. J. Durant et al., Cyanoguanidine-Thiourea Equivalence in the Development of the Histamine H2-Receptor Antagonist, Cimetidine, Journal of Medicinal Chemistry (1977), vol. 20, No. 7, 901-906.

Affiliated with

Also associated with

Rating

Process for the preparation of chlorothiazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of chlorothiazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of chlorothiazole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-103009