Process for the preparation of chloromethyl...

Details Process for the preparation of chloromethyl... Process for the preparation of chloromethyl...

2006-09-29

2011-10-18

Keys, Rosalynd (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S681000, C568S683000

Reexamination Certificate

active

08039678

ABSTRACT:
The present invention refers to a process for the preparation of chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether (sevochlorane), which consists of reacting hexafluoroisopropanol with: a formaldehyde equivalent selected between paraformaldehyde or 1,3,5-trioxane, a chlorinating agent selected from the group consisting of oxalyl chloride, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, sulfuryl chloride and thionyl chloride, and a strong acid selected from the group consisting of concentrated or fuming sulfuric acid. Said process provides sevochlorane in high purity and yield, which can be converted to sevoflurane by known means.

REFERENCES:
patent: 4225677 (1980-09-01), Boutier et al.
patent: 5811596 (1998-09-01), Kawai et al.
patent: 6100434 (2000-08-01), Bieniarz et al.

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