Process for the preparation of chiral, nonracemic (4-aryl-2,5-di

Details Process for the preparation of chiral, nonracemic (4-aryl-2,5-di Process for the preparation of chiral, nonracemic (4-aryl-2,5-di

1997-06-19

2000-01-25

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483171, C07D23376, C07D23380, C07D23372, C07D23378

Patent

active

060180536

ABSTRACT:
The present invention relates to a process for the preparation of chiral, nonracemic compounds of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings indicated in claim 1 and which are useful intermediates for the preparation of pharmaceutical active compounds in which, for resolution, a salt is formed from the racemic compound of the formula I and a chiral, nonracemic amino compound. It furthermore relates to compounds of the formula I and esters thereof.

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M. B. Winstead et al., "Substitution in the Hydantoin Ring. I. N-3-Aminomethyl Derivatives," and "Substitution in the Hydantoin Ring. II. N-3-Acetic Derivatives," Notes, vol. 8, pp. 117-122 (Jan. 1965).
H.U. Stilz et al., "From Peptides to Heterocyclic Peptide Mimetics--Design and Synthesis of an Orally Active Fibrinogen Receptor Antagonist for the Prevention of Thrombosis," Bull. Soc. Chim. Belg., vol. 105, No. 10-11, pp. 711-719 (1996).
J. Falbe et al., "Racemattrennung," Rompp Chemic Lexikon, vol. 9 No. 5, pp. 3753-3754 (1992).

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