Process for the preparation of chiral ketone intermediates usefu

Details Process for the preparation of chiral ketone intermediates usefu Process for the preparation of chiral ketone intermediates usefu

1997-09-12

1999-06-01

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546219, 546220, 546221, 546222, 546186, 546194, 546208, 546210, 546213, 546214, C07D21174

Patent

active

059089342

ABSTRACT:
A process for the preparation of compounds of formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3, m, n and q are as defined herein; which comprises the steps of (a)reacting a compound of formula III ##STR2## with a chiral acid in an organic solvent to form a salt of a compound of formula I and (b) treating the salt of a compound of formula I with an aqueous base to obtain the compounds of formula I. Compounds of formula I are intermediates useful in the preparation of protein kinase inhibitors.

REFERENCES:
patent: 4900727 (1990-02-01), Kattige et al.
patent: 5733920 (1998-03-01), Mansuri et al.
Baylet et al., "Resolution of Racemates by Diastereomeric Salt Formation," Chirality in Industry, pp. 69-77, 1992.
Jacques et al., "Enantiomers, Racemates, and Resolutions," pp. 380-383, 1981.
Morrison, "Organic Chemistry," Chapter 4, pp. 163-166, 1979.

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