Process for the preparation of chiral 1-aryl-2-aminopropanes

Details Process for the preparation of chiral 1-aryl-2-aminopropanes Process for the preparation of chiral 1-aryl-2-aminopropanes

1992-12-18

1994-11-01

Hollrah, Glennon H.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435193, 435913, 435874, 435832, 435940, 435930, 435921, 435886, 564275, 564375, 564424, C12P 1300

Patent

active

053607244

ABSTRACT:
One chiral form of a 1-aryl-2-aminopropane is produced in preference to its enantiomer by allowing a 1-arylpropan-2-one to react with a 1-amino-1-phenylethane of predominantly one chiral form and reducing the resultant 1-(1-arylprop-2-ylideneimino)-1-phenylethane to yield phenylethane and a mixture of 1-aryl-2-aminopropanes in which one chiral form thereof is present in preference to its enantiomer. The mixture of 1-aryl-2-aminopropanes then is subjected to the action of an omega-amino acid transaminase which converts one of the two chiral forms of 1-aryl-2-aminopropane into the corresponding arylpropanone which can be separated from the remaining chiral form of the 1-aryl-2-aminopropane.

REFERENCES:
patent: 4000197 (1976-12-01), Barfknecht
patent: 5169780 (1992-12-01), Stirling

Affiliated with

Also associated with

Rating

Process for the preparation of chiral 1-aryl-2-aminopropanes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of chiral 1-aryl-2-aminopropanes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of chiral 1-aryl-2-aminopropanes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1802047