Process for the preparation of certain nitrogen-containing mono-

Details Process for the preparation of certain nitrogen-containing mono- Process for the preparation of certain nitrogen-containing mono-

1987-03-12

1989-07-11

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548158, 548533, C07D20716, C07D20996

Patent

active

048473847

ABSTRACT:
An improved process for preparing certain nitrogen-containing mono- and bicyclic ACE inhibitors comprising reacting an .alpha.-alkyl amino acid with a disulfide compound to form a thioester intermediate, which intermediate is then amidated with a mono- or bicyclic amino acid. The invention also relates to the novel thioester intermediates prepared by the first step of the process.

REFERENCES:
patent: 1958770 (1934-05-01), Sebrell
patent: 4325945 (1982-04-01), Natarajan et al.
patent: 4506082 (1985-03-01), Crossley
patent: 4512979 (1985-04-01), Patchett et al.

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