Process for the preparation of cephem derivatives

Details Process for the preparation of cephem derivatives Process for the preparation of cephem derivatives

1992-10-13

1994-05-31

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540227, 540228, 540230, C07D50106

Patent

active

053170997

ABSTRACT:
A process for preparing B-lactam derivatives of the formula (I): ##STR1## wherein R.sup.1 represents hydrogen or a metal salt; and R.sup.2 represents hydrogen, acetoxy methyl, (2,5-dihydro-2-methyl-6-hydroxy-5-oxo-as-triazin-3-yl)thiomethyl or (1-methyl-1-H-tetrazol-5-yl)thiomethyl is disclosed. This process comprises the steps of (a) reacting triphenylphosphine and hexachloroethane or carbon tetrachloride with 2-(2-aminothiazol-4-yl)-2-syn-methoxyimino acetic acid in an organic solvent to give the corresponding acyloxyphosphonium chloride derivative of the formula: ##STR2## (b) acylating a previously silylated derivative of 7-ACA with this acyloxyphosphonium chloride derivative without its isolation.

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