Process for the preparation of cephamycin antibiotics

Details Process for the preparation of cephamycin antibiotics Process for the preparation of cephamycin antibiotics

1979-03-30

1980-09-02

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50120

Patent

active

042207622

ABSTRACT:
An improved process for preparing the antibiotic compound 7.beta.-(2-thienylacetamido)-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-car boxylic acid, from the N-blocked esters of the compound 7.beta.-(D-5-amino-5-carboxyvaleramido)-3-carbamoyloxymethyl-7-methoxy-3-c ephem-4-carboxylic acid (Cephamycin C), by conducting the transacylation of the latter in a homogeneous solution containing a trimethylsilyl enol ether.

REFERENCES:
patent: 4014873 (1977-03-01), Christensen et al.
patent: 4053286 (1977-10-01), Weinstock

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