Process for the preparation of cephalosporins

Details Process for the preparation of cephalosporins Process for the preparation of cephalosporins

1994-07-12

1997-04-29

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540227, C07D50106

Patent

active

056250584

ABSTRACT:
The present invention relates to a process for the preparation of 7-(.alpha.-hydroxyacylamino)-3-(1-sulphoalkyl-tetrazol-5-yl-thiomethyl)-3- cephem-4-carboxylic acids and relevant salts, via acylation of a 7-amino-3-(1-sulphoalkyl-tetrazol-5-yl-thiomethyl)-3-cephem-4-carboxylic acid with the corresponding chloride of .alpha.-formyl oxycarboxylic acid in a diluent, at pH 6.5-7.0; deformylation by treatment with an acid at pH between 0.5 and 1.5; extraction/s with an organic solvent of the acid aqueous phase from deformylation, followed by salting out and extraction with a solvent selected among tetrahydrofuran, methylethylketone, and acetonitrile; solvent evaporation and salification in a non-aqueous medium.

REFERENCES:
patent: 4048311 (1977-09-01), Berges
patent: 4093723 (1978-06-01), Berges
patent: 4139701 (1979-02-01), Berges
patent: 4159373 (1979-06-01), Berges
patent: 4576937 (1986-03-01), Polansky

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