Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1982-09-03
1984-06-26
Coughlan, Jr., Paul M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544 26, 544 27, C07D50106
Patent
active
044567545
ABSTRACT:
Novel thioesters effective as acylating agents for amines or hydrazines, especially effective as active esters in synthesis of cephalosporin compounds are disclosed. The novel thioester of the present invention can be prepared by reacting a thiol or a derivative thereof with an acetic acid derivative or a reactive derivative thereof. By reacting the thioester of the present invention with a 7-aminocephalosporin derivative or a salt thereof, cephalosporin derivatives or pharmacologically acceptable salts thereof which are excellent antibiotic substances having a high antimicrobial activity can be obtained in high yield very safely.
REFERENCES:
patent: 3946003 (1976-03-01), Cooper
patent: 4144391 (1979-03-01), Hatfield
patent: 4314059 (1982-02-01), Shibuya et al.
patent: 4316024 (1982-02-01), Iimura et al.
patent: 4351947 (1982-09-01), Shibuya et al.
Kobayashi Masateru
Murakami Masahiro
Shibuya Chisei
Yamamoto Kimiyo
Asahi Kasei Kogyo Kabushiki Kaisha
Coughlan, Jr. Paul M.
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