Process for the preparation of cephalosporin derivatives using t

Details Process for the preparation of cephalosporin derivatives using t Process for the preparation of cephalosporin derivatives using t

1982-09-03

1984-06-26

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 26, 544 27, C07D50106

Patent

active

044567545

ABSTRACT:
Novel thioesters effective as acylating agents for amines or hydrazines, especially effective as active esters in synthesis of cephalosporin compounds are disclosed. The novel thioester of the present invention can be prepared by reacting a thiol or a derivative thereof with an acetic acid derivative or a reactive derivative thereof. By reacting the thioester of the present invention with a 7-aminocephalosporin derivative or a salt thereof, cephalosporin derivatives or pharmacologically acceptable salts thereof which are excellent antibiotic substances having a high antimicrobial activity can be obtained in high yield very safely.

REFERENCES:
patent: 3946003 (1976-03-01), Cooper
patent: 4144391 (1979-03-01), Hatfield
patent: 4314059 (1982-02-01), Shibuya et al.
patent: 4316024 (1982-02-01), Iimura et al.
patent: 4351947 (1982-09-01), Shibuya et al.

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