Process for the preparation of cephalosporin derivatives

Details Process for the preparation of cephalosporin derivatives Process for the preparation of cephalosporin derivatives

1987-01-09

1989-05-30

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540230, 540227, C07D50144, A61K 31545

Patent

active

048352675

ABSTRACT:
The present invention relates to an improved process for producing cephalosporin derivatives of formula (I), the 3-position of which being substituted by acetoxymethyl or tetrazolylthiomethyl and the 7-acyl group of which being substituted by D-mandelic acid derivatives, which comprises simultaneously reacting the compound of formula (III) with the compound of formula (IV) in the presence of a compound of formula (II) and anamine in high yield, ##STR1## wherein, R.sup.1 is hydrogen or ##STR2## R.sup.2 is methyl, ethyl, propyl or phenyl, X is ##STR3##

REFERENCES:
patent: 4007168 (1977-02-01), Coll

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