Process for the preparation of castanospermine esters

Details Process for the preparation of castanospermine esters Process for the preparation of castanospermine esters

1989-08-08

1990-11-13

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D22102

Patent

active

049703170

ABSTRACT:
1-Esters of castanospermine have been prepared enzymatically from appropriate activated esters using substilisin. The esters obtained in this way can be further reacted enzymatically to give diesters which can, in turn, be selectively hydrolyzed to give monoesters in good yield.

REFERENCES:
M. Therisod et al., J. Am. Chem. Soc., 108, 5638 (1986).
H. M. Sweers et al., J. Am. Chem. Soc., 108, 6421 (1986).
M. Therisod et al., J. Am. Chem. Soc., 109, 3977 (1987).
S. Riva et al., J. Am. Chem. Soc., 110, 584 (1988).
S. Riva et al., J. Am. Chem. Soc., 110, 3291 (1988).
W. J. Hennen et al., J. Org. Chem., 53, 4939 (1988).
F. Nicotra et al., Tet. Letters, 30, 1703 (1989).
F. Bjorkling et al., J. Chem. Soc., Chem. Commun., 1989, 934.

Affiliated with

Also associated with

Rating

Process for the preparation of castanospermine esters does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of castanospermine esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of castanospermine esters will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-777866