Process for the preparation of carvedilol form-II

Details Process for the preparation of carvedilol form-II Process for the preparation of carvedilol form-II

2004-04-16

2008-12-23

Shameem, Golam M (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S416000, C548S427000, C548S439000, C548S440000

Reexamination Certificate

active

07468442

ABSTRACT:
The present invention provides a cost-effective, industrially feasible process for the manufacture of crystalline Carvedilol Form-II using novel Carvedilol salts comprising a step of reacting 4-(2,3-epoxy propoxy)carbazole (II) with 2-(2-methoxy phenoxy)ethyl amine (III) followed by acidification with mineral acid in presence of an organic solvent to yield acid addition salts, treatment of the said salts with base(s) in presence of organic solvent(s), water and isolation from the organic solvent(s) followed by crystallization from ethyl acetate.

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patent: WO 02/00216 (2002-01-01), None

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