Process for the preparation of carebastine and similar materials

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435911, C12P 1712, C12N 114, C07D21146

Patent

active

052042499

ABSTRACT:
The invention relates to a novel process for the preparation of carebastine and similar materials from ebastine or terfenadine by oxidization using microorganisms. Carebastine and similar materials are used for the treatment of allergic disorders and as antihistamines.

REFERENCES:
patent: 3822188 (1974-07-01), Fager et al.
patent: 4064009 (1977-12-01), Fukuda et al.
patent: 4153509 (1979-05-01), Schwartz
patent: 4996149 (1991-02-01), Jarreau et al.
ATCC "Catalogue of Fungi/Yeasts" 17th Ed. 1987 pp. 126-127.

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