Process for the preparation of carboxylic acid succinimidyl este

Details Process for the preparation of carboxylic acid succinimidyl este Process for the preparation of carboxylic acid succinimidyl este

1997-12-30

1999-07-27

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20712

Patent

active

059292512

ABSTRACT:
Process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 together form a C.sub.6 -aryl radical, in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. and isolation of the corresponding carboxylic acid succinimidyl ester.

REFERENCES:
patent: 4341707 (1982-07-01), Ogura et al.
patent: 5459131 (1995-10-01), Albright et al.
patent: 5734064 (1998-03-01), Pochlauer et al.

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