Process for the preparation of carboxylic acid succinimidyl este

Details Process for the preparation of carboxylic acid succinimidyl este Process for the preparation of carboxylic acid succinimidyl este

1997-04-04

1998-03-31

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20746

Patent

active

057340641

ABSTRACT:
A process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## is desired, in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 The process is carried out in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. with isolation of the corresponding carboxylic acid succinimidyl ester.

REFERENCES:
patent: 4341707 (1982-07-01), Ogura et al.
patent: 5459131 (1995-10-01), Albright et al.
Chemical Abstracts,93:205006y, (1980).
Chemical Abstracts,95;203746g, (1981).
Chemical Abstracts,107:116062d, (1987).

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